International Journal of Chemistry and Material Science Vol. 1(7), pp. 189-194, July, 2013 ISSN 2327-5553 ©2013 Academe Research Journals


Full Length Research Paper

Utility of azalactones in synthesis of some new heterocyclic compounds

Sameh A. Rizk

Chemistry Department, Ain Shams University, Abbassia, Cairo, Egypt. E-mail:

Accepted 13 May, 2013


Azalactone 1 can be synthesized via treatment of 4- chlorobenzoyl glycine with p-anisaldehyde in the presence of acetic anhydride and sod Acetate. The behaviour of azalactone 1 towards nitrogen nucleophiles, for example, anthranilic acid, 6-aminopyrimidin-2,4-dione and 2-amino-6-phenyl 1,3,4-thiadiazole can be investigated. Benzoxazone 2 can be treated with hydrazine hydrate, hydroxylamine hydrochloride, and o-phenylenediamine in different reaction conditions to afford quinazolinone derivatives 3, 4, 5, 6. The imidazoloquinazolinone derivative 6 can be treated with hydrazine derivatives. Pyrimidino/thiadiazolopyrimidine 8, 11 can be treated with acetic anhydride to increase their biological activities. The structures of all synthesized compounds were confirmed from analytical as well as spectral data.

Key words: Azalactone, benzoxazinone, quinazolinone, fused pyrimidinopyrimidine, 1,3,4-thiadiazolopyrimidine, Schiff’s base.